User talk:Doc James

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Image

Hi there, please can you modify or remove this illustration? It incorrectly depicts a measles virus in the environment binding to the surface of an epithelial cell. However initial infection targets macrophages in the lining of the airways. In a later stage of infection, the virus infects epithelial cells but fuses to the binding protein nectin-4 having been transported in the bloodstream.

Thanks!! Bob (talk) 20:09, 6 August 2026 (UTC) Bob (talk) 20:09, 6 August 2026 (UTC)

Yes appears understanding has changed from:

"The current model of measles virus (MV) pathogenesis implies that apical infection of airway epithelial cells precedes systemic spread." to

"MeV does not directly infect epithelial cells upon entry in a new host. MeV traverses the epithelium within immune cells that carry it to lymphatic organs where amplification occurs. Infected immune cells then synchronously deliver large amounts of virus to the airways."

Doc James (talk · contribs · email) 20:30, 6 August 2026 (UTC)

It does use SLAMF1 to attach to macrophages and it does use nectin-4 for epithelial cells eventually.

Text of the videoscript is thus dated aswell. I guess the question is what should we update it to? Doc James (talk · contribs · email) 20:35, 6 August 2026 (UTC)

Apologies for late reply, I wasn't monitoring your talk page. I'm not sure how easy it is to change an illustration ..... I would suggest adding a macrophage straddling the epithelial cells, being attacked by the virion. I was hoping to find something similar in Wikimedia but I'm short of time!

Bob (talk) 09:24, 3 September 2026 (UTC)

And how do you think we should update the text? Should the macrophage be on top of the epithelial cells or between them? Doc James (talk · contribs · email) 10:47, 3 September 2026 (UTC)

@Doc James - I'm well out of my depth here, I'm sure you have better sources than I do. I found a couple of micrographs - one shows between, the other shows on top, so take your pick. Halfway?? Bob (talk) 22:08, 3 September 2026 (UTC)

User:Robertpedley Something like this? If you agree can get someone to make a better version. Doc James (talk · contribs · email) 08:57, 4 September 2026 (UTC)

Yes, I think that would do it nicely. Many thanks!! Bob (talk) 21:11, 7 September 2026 (UTC)

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